Cabergoline Relieved Painful Breast Symptoms After Second-Trimester Pregnancy Loss

High levels of prolactin hormone can cause problems such as breast milk production in higher amounts, missing out on periods, or difficulty in getting pregnant. The pharmacokinetic and metabolic profiles of cabergoline have been studied in healthy volunteers of both sexes, in female hyperprolactinemic patients and in parkinsonian patients. After oral administration of the labelled compound, radioactivity was rapidly absorbed from the gastrointestinal tract as the peak of radioactivity in plasma was between 0.5 and 4 hours.

  • The product should be administered orally either directly into the mouth or by mixing with food.
  • Animal studies have not demonstrated teratogenic effects, but reduced fertility and embryo-toxicity were observed in association with pharmacodynamic activity (see section 5.3).
  • All patients must undergo a cardiovascular evaluation, including echocardiogram to assess the potential presence of asymptomatic valvular disease.
  • Improvement of motor deficit in animal models of Parkinson’s disease was present at oral daily doses of 1-2.5 mg/kg in rats and at s.c.
  • Each time you collect a fresh supply, check to see if the tablets look the same as you have had before.

Males with high prolactin levels may have difficulties reproducing and may experience sexual issues. Reduced sexual desire and difficulty in acquiring or sustaining an erection are examples of these symptoms. It is utilized to treat menstrual issues and fertility issues in both women and men, as well as pituitary prolactinomas (tumors of the pituitary gland). It stops the brain from producing and releasing prolactin hormone through the pituitary gland.

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The safety and efficacy of cabergoline has not been investigated in children as Parkinson’s disease does not affect this population. Patients should be careful when performing actions which require fast and accurate reaction during treatment initiation. Cabergoline should be discontinued if an echocardiogram reveals new or worsened valvular regurgitation, valvular restriction or valve leaflet thickening (see section 4.3). Cabergoline restores ovulation and fertility in women with hyperprolactinaemic hypogonadism. The effects of alcohol on overall tolerability of cabergoline are currently unknown.

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The prescribing doctor may decide to increase this by 0.25mg taken twice a week. It is important for patients to note that the dosage prescribed can depend on the patient`s serum prolactin levels, and for this reason, it is very important to follow the prescribing doctor`s instructions. Women affected by high prolactin levels may notice symptoms such as excessive or unnecessary production of breast milk, missed periods or difficulty becoming pregnant.

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Postural hypotension can occur following administration of cabergoline, particularly during the first days of administration of cabergoline. Care should be exercised when administering cabergoline concomitantly with other drugs known to lower blood pressure. There were maternotoxic effects but no teratogenic effects in mice given cabergoline at doses up to 8 mg/kg/day (approximately 55 times the maximum recommended human dose) during the period of organogenesis. No information is available on the excretion in breast milk in humans; however, mothers should be advised not to breast-feed in case of failed lactation inhibition/suppression by cabergoline. Since it prevents lactation, cabergoline should not be administered to mothers with hyperprolactinemic disorders who wish to breast-feed their infants.